The Domain of Anguish is an "elite" region in the Nightfall campaign. The domain consists of one outpost, four explorable areas and an Elite Mission.

According to lore, the Domain of Anguish is the place within the Realm of Torment that the evil forces of Abaddon retreated to after the defeat of their dark lord. From this fall-back position they try to re-build a bastion of power, and to threaten the Goddess of Truth. Players may venture into the Domain to stop the demons from succeeding.